NLRP3 and hyperhomocysteinemia: Activation of NLRP3 inflammasome has been shown to be involved in podocyte injury and glomerular sclerosis in hyperhomocysteinemia, and inhibition of NADPH oxidase or knockdown of ASC or caspase-1 inhibition may play a protective effect (Zhang et al., 2012; Abais et al., 2013).