FSCN1 and neoplasm: The fascin protein encoded by Fscn1 organizes F-actin into bundles needed to form cellular protrusions that enhance tumor cell migration (26), and the actin-rich podoplanin protein encoded by Pdpn enhances tumor cell invasion, most likely by stabilizing invadopodia that trigger extracellular matrix (ECM) degradation (27, 28).