Studies employing murine and human tumor cell lines have confirmed the oncogenic potential of the FOXC2 transcription factor, highlighting its ability to promote several hallmarks of cancer progression, including proliferation (5, 9), epithelial-mesenchymal transition (EMT) (10), invasion and metastasis (11), glycolytic metabolism (12), stemness (13), and drug resistance (14, 15). The gene discussed is FOXC2; the disease is cancer.