FOXC2 and melanoma: With 5 replicate RNA samples isolated from each tumor cell line, a Quality score of Q30 >82% for each sample (Q30 = 99.9% base calling accuracy), and a high level of correlation between samples within each biological group (Pearson R2 correlation > 0.993 between replicates, Figure 1A), this dataset provides a high-quality profile of the FOXC2-associated transcriptome in melanoma cells, and it will serve as a useful tool to investigators interested in studying FOXC2 function in the context of cancer.