Additionally, FOXC2-associated downregulation of genes belonging to the Focal adhesion pathway (mmu04510), such as the fibronectin-encoding Fn1 gene and the integrin-encoding Itgb3 gene, the latter of which is a known direct target of FOXC2 (29), may contribute to ECM remodeling and the altered adhesion of tumor cells to ECM components that occurs during the invasion process. This evidence concerns the gene FOXC2 and neoplasm.