By Northern blotting, Dhahbi et al. confirmed 5′ RNY4 fragments in plasma of HD (48), Haderk et al. validated the presence of both RNY4 full-length and 5′ fragments in CLL exosomes (53), whereas Driedonks et al. showed that EV released from dendritic cells mostly contain full-length RNY1 and only small amounts of 19–35 nt RNY1 fragments (58). The gene discussed is RNY1; the disease is B-cell chronic lymphocytic leukemia.