RNY4 and anaplastic large cell lymphoma: Of note, most of the full-length RNY4 was inside exosomes (5.6 times more abundant inside, on average) of both HD (Mann-Whitney p = 0.009) and ALCL patient (p = 0.002) samples, whereas the fragment was present at a similar level in exosomes and as free circulating RNA (Figure 2B).