To characterize the exosomal load of sRNAs in ALCL patients and disclose differences with healthy donors, sRNAs were examined by small RNA-seq of exosomes from 20 ALK-positive ALCL patients and five HD plasma samples, and from supernatant of five ALCL cell lines (Karpas299, SUDHL1, and SUP-M2, ALK-positive; FE-PD and MAC2A, ALK-negative). The gene discussed is ALK; the disease is anaplastic large cell lymphoma.