VEGFA and glioblastoma: Bevacizumab (BVZ), a humanized anti-VEGF monoclonal antibody, was the first drug to be approved by the Food and Drug Administration (FDA) for the treatment of metastatic colon, ovarian, renal, non-squamous cell lung cancer (NSCLC), and glioblastoma mutliforme (GBM) (66, 67).