PKC-ζ has been shown to be involved in tumorigenesis, tissue invasion, and cancer progression through the modulation of cell migration machinery, such as Ras Homolog Family Member A (RhoA), Rac Family Small GTPase 1 (Rac1), and Epithelial Cell Transforming 2 (Ect2) (14–16). The gene discussed is RHOA; the disease is cancer.