The mRNA levels in the BM samples from 37 AML patients (M0 n = 1, M1 n = 2, M2 n = 9, M3 n = 12, M5 n = 12, M6 n = 1) and serum SPRED1 protein concentrations in the serum samples from 27 AML patients were compared both at diagnosis and after induction treatment. This evidence concerns the gene SPRED1 and acute myeloid leukemia.