SPRED1 and acute myeloid leukemia: As reduction of SPRED1 occurred much more frequently than did elevation of MIR126 in this study (87.6 vs. 36.2%) and no distinction of SPRED1 expression was observed between CBF AML and AML with other recurrent chromosomal abnormalities, we speculate that upregulation of MIR126 is not the major underlying mechanism of SPRED1 reduction even if it does impact the SPRED1 expression in certain subgroup of AML.