Downregulation of the transcription factor Id1 reduces vascular endothelial growth factor A (VEGF-A) and lymphatic endothelial growth factor C (LEGF-C), thereby inhibiting tumor angiogenesis and growth, and it facilitates cell differentiation through upregulating the expression of cytokeratin 13 or 15 (44–46). The gene discussed is VEGFA; the disease is neoplasm.