AVP and hypertensive disorder: In addition, the increased AVP level in SHRs is in accordance with the hypothesis that SHRs have high AVP release i.e., high transcription of AVP as increasing levels of mineralocorticoid receptor and mineralocorticoids have been regarded to be involved in central regulation of BP, and they are known to drive the release of AVP to maintain hypertension (Carmichael & Wainford, 2015; Pietranera et al., 2012).