Temsirolimus is used to treat advanced RCC, while everolimus is used to treat RCC that has failed to respond to sunitinib or sorafenib, in combination with exemestane for breast cancer with hormone receptor (+) and Her2 (−), pancreatic neuromedicinal tumors (pNET) and subependymal giants-cell astrocytoma (SEGA). The gene discussed is NR4A1; the disease is subependymal giant cell astrocytoma.