Temsirolimus is used to treat advanced RCC, while everolimus is used to treat RCC that has failed to respond to sunitinib or sorafenib, in combination with exemestane for breast cancer with hormone receptor (+) and Her2 (−), pancreatic neuromedicinal tumors (pNET) and subependymal giants-cell astrocytoma (SEGA). This evidence concerns the gene ERBB2 and subependymal giant cell astrocytoma.