In addition, Chen et al. [78] found in breast cancer that mTOR inhibitor AZD8055 can prevent the heat shock protein (HSP) 90 inhibitor AUY922 from up-regulating the response of HSP70 and HSP27 in breast cancer, while HSP90 inhibitor can block the activation of PI3K/Akt caused by mTOR inhibitor. The gene discussed is AKT1; the disease is breast cancer.