MED12 and FG syndrome: Mutations of the MED12 gene can cause MED12-related syndrome, a disease that varies in its clinical manifestations (Charzewska et al., 2018) and currently has at least four different subtypes: Opitz-Kaveggia syndrome (FGS1); Lujan syndrome (LS); Ohdo syndrome, the Maat-Kievit-Brunner type (OSMKB); and nonspecific intellectual disability (NSID) (Graham and Schwartz, 2013; Tzschach et al., 2015).