In this context, aberrant expression and function of miRNAs, such as miR-33, miR-208, miR-133, and miR-124, have been shown to be associated with lipid metabolism, insulin secretion, myocardial infarction and T2D (Stauffer et al., 2013; Rotllan et al., 2016; Wang et al., 2017). This evidence concerns the gene INS and type 2 diabetes mellitus.