Given that FITM1 belongs to a protein family with unique structure and involves in the key progress of lipid metabolism, the aberrant methylation state of FITM1 might result in disorder lipid homeostasis and NAFLD (Gross et al., 2011; Goh and Silver, 2013), triggering the carcinogenesis and progression of the non-viral HCC. The gene discussed is FITM1; the disease is metabolic dysfunction-associated steatotic liver disease.