And FES, ABCG5, GPX7, FURIN, BSCL2, and B3GALNT1 had 2 methylation curves and the comparison of methylation level in tumors and normal tissues was ambiguous, driving us to elucidate the gene methylation and expression level between malignant samples and normal samples in non-viral HCC patients. Here, FURIN is linked to hepatocellular carcinoma.