Mechanistically, PTEN up-regulates MALAT1 expression by binding and sequestering miR-17, miR-20a and miR-106b, and MALAT1 suppresses colorectal and breast cancer cell migration and invasion by reducing the pro-metastatic Epithelial Cell Adhesion Molecule (EpCAM) and ITGB4 (Kwok et al., 2018). This evidence concerns the gene ITGB4 and breast carcinoma.