While miR-200c-3p and miR-217 induce MALAT1 RNA degradation, MALAT1 suppresses miR-200c-3p and miR-217 function and miR-217 translocation from the nucleus to the cytoplasm, up-regulates ZEB1 and KRAS expression, and induces pancreatic cancer cell migration and invasion (Liu et al., 2017; Zhuo et al., 2018). Here, MALAT1 is linked to familial pancreatic carcinoma.