By interacting with EZH2, SUZ12, and a number of miRNAs, MALAT1 increases the expression of oncogenic factors, such as N-cadherin, β-catenin, c-Myc, ZEB1, and KRAS, decreases the expression of tumor suppressing factors, such as E-cadherin, p21, and p27, and induces cancer cell proliferation, migration and invasion in vitro, and tumor metastasis in mice. The gene discussed is EZH2; the disease is neoplasm.