ITGB4 and neoplasm: MALAT1 binds and sequesters the transcription factor TEAD proteins and thus blocks TEAD proteins from association with their co-activator YAP protein and target gene promoters, leading to transcriptional suppression of genes important for tumor metastasis, including integrin β4 (ITGB4) and vascular endothelial growth factor (VEGF) (Kim et al., 2018) (Figure 1B).