MMP14 and melanoma: By binding miR-34a and miR-22 and regulating miR-34a and miR-22 function, MALAT1 up-regulates c-Myc, Met, MMP14, and snail expression, promotes melanoma cell proliferation, invasion, and migration in vitro, and is required for melanoma progression in mice (Luan et al., 2016; Li et al., 2019).