MALAT1 consists of sequence-specific miR-34a- and miR-22-binding sites, binds miR-34a and miR-22, and regulates miR-34a and miR-22 function, leading to up-regulation of c-Myc, Met, MMP14, and snail in melanoma cells (Luan et al., 2016; Li et al., 2019). The gene discussed is MALAT1; the disease is melanoma.