EZH2 and neoplasm: In addition, it has been shown that MALAT1 is required for PRC2 complex binding to gene promoters and consequent regulation of gene transcription, as MALAT1 knockdown dissociates EZH2 protein from the gene promoters of tumor suppressors, such as p21 and p27, and reverses EZH2-mediated gene silencing (Wang et al., 2016) (Figure 1A).