By interacting with the PRC2 component protein EZH2 and facilitating histone H3K27 trimethylation, MALAT1 suppresses p21, p27, and E-cadherin expression and thereby increases β-catenin and c-Myc expression, leading to mantle cell lymphoma and renal cell carcinoma cell survival, proliferation, and invasion (Hirata et al., 2015; Wang et al., 2016). Here, MALAT1 is linked to hereditary clear cell renal cell carcinoma.