MALAT1 and neoplasm: However, in these studies, the authors usually employ tumor samples from small cohorts of patients, and use MALAT1 antisense oligonucleotides, small interfering RNAs (siRNAs), or short hairpin RNA (shRNAs), without in vitro and in vivo rescue experiments, to demonstrate the specificity of the MALAT1 antisense oligonucleotides, siRNAs, and shRNAs.