CDK4 and breast cancer: By sponging miR-206, MALAT1 up-regulates ANXA2 and KRAS expression in gallbladder cancer cells (Wang et al., 2016), and reduces CDC42 and up-regulates CDK4 expression in breast cancer cells (Chou et al., 2016; Feng et al., 2016; Bamodu et al., 2016) (Table 1).