MYCN and neoplasm: For example, N-Myc oncoprotein up-regulates the histone demethylase JMJD1A which in turn up-regulates MALAT1 in human neuroblastoma cells, and that MALAT1 induces tumor-driven endothelial cell migration, invasion, and angiogenesis as well as tumor cell migration, invasion, and metastasis (Tee et al., 2014; Tee et al., 2016).