By association with the other PRC2 component protein SUZ12, MALAT1 decreases E-cadherin expression and increases N-cadherin and fibronectin expression, leading to epithelial mesenchymal transition (EMT), bladder cancer cell migration, and invasion in vitro and tumor metastasis in animal models (Fan et al., 2014). This evidence concerns the gene CDH1 and urinary bladder carcinoma.