In vitro studies show that MALAT1 forms a direct RNA-protein complex with the pro-metastatic transcription factor TEAD, prevents TEAD from associating with its co-activator YAP, suppresses the binding of YAP and TEAD to the promoters of their target genes, such as ITGB4 and VEGF, decreases YAP-TEAD target gene expression, and suppresses breast cancer cell migration and invasion (Kim et al., 2018). This evidence concerns the gene VEGFA and breast carcinoma.