Neither overall meta-analyses nor stratified analyses identified an association of the <i>IL-10</i> rs1800869 and rs1800871 polymorphisms with susceptibility to CKD.<h4>Conclusions</h4>Available data suggest that common polymorphisms in the <i>TGF-β1</i> and <i>IL-4</i> genes including rs1800469, rs1800470, rs1800471, and rs8179190 may be important genetic contributors to CKD susceptibility. Here, IL4 is linked to chronic kidney disease.