RYR1 and Malignant hyperthermia: RyR variants have been associated with a number of pathologies, most notably myopathies, including malignant hyperthermia (MH) (Robinson et al., 2006), age-related decline in skeletal muscle function (Boncompagni et al., 2006; Andersson et al., 2011), and heart arrhythmia (Salvage et al., 2019).