Mass cytometry analysis of myeloid (CD11b+) cells, neutrophils/MDSCs (CD11b+/Ly6G+), monocytes (CD11b+/Ly6C+), macrophages (CD11b+/F4/80+), MHC-II+, CD206+, and PD-L1+ macrophages (Figure 5A) and T cells (CD3+), helper T-cells (CD3+/ CD4+), regulatory T cells (CD3+/CD4+/CD25+), cytotoxic T cells (CD3+/CD8+), activated/exhausted cytotoxic T cells (CD8+/CD69+; CD8+/PD-1+) (Figure 5B) from pancreatic tumors from control vs. anti-Gas6 treated mice did not show any significant differences (Figures 5A,B, Supplementary Figures 4A,B). Here, CD8A is linked to pancreatic neoplasm.