PMEL and neoplasm: - CS-NPs with the adjuvant revealed comparable levels of anti-OVA IgG titers to SC injection of an OVA solution, - Significantly higher IgG-levels after topical application of OVA-loaded CS-NPs in comparison to topical application of an OVA solution - Higher survival rate of tumor-bearing mice after TCI with antigen gp100-loaded CS-NP in comparison to gp 100 antigen solution