For example, in HFD-induced obese and diabetic mice fed with curcumin, an amelioration of diabetes (in the context of glycemic status and insulin sensitivity) and obesity-associated inflammation was observed, together with decreased NF-kB activity in the liver, reduced macrophage infiltration into WAT and elevated adiponectin production (94). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.