TXNIP and Hyperglycemia: In another study examining the epigenetic effects of glucose on the expression of the proinflammatory gene, thioredoxin-interacting protein (TXNIP), in diabetic Sur1-E1506K+/+ mice, it was discovered that the p300 inhibitor C646 reverses histone acetylation and consequently, represses hyperglycemia-stimulated TXNIP expression (97) (Figure 3B).