In a study conducted by Picard et al. to investigate the homeostatic effects of TIF2 in two obesity models (high-fat feeding and neonatal injection of monosodium glutamate), the authors discovered that in the absence of TIF2, mice are resistant to the development of obesity (91) (Figure 3B). The gene discussed is NCOA2; the disease is obesity due to melanocortin 4 receptor deficiency.