INS and obesity due to melanocortin 4 receptor deficiency: NaB supplementation led to higher energy expenditure and fatty acid oxidation, a reduction in fasting blood glucose and insulin levels, improved intraperitoneal insulin tolerance, enhanced BAT thermogenic activity upon cold exposure, upregulation of UCP-1 and PGC-1α mRNA expression, as well as an increase in type I skeletal muscle fibers, Additionally, there was a loss of 10.2% in body weight and 10% in fat content in the diet-induced obese mice model—all in all, signifying that administration of NaB led the mice to become resistant to obesity and insulin resistance (135).