SAMD12 and benign adult familial myoclonic epilepsy: In the report of the Japanese BAFME pedigrees, there were no obvious alterations in SAMD12 transcript 1 levels observed in patient's brain, but RNA lesions were observed in cortical neurons and Purkinje cells, which was consistent with MRI findings, suggesting that RNA-mediated toxicity might be the basis of the pathogenesis in BAFME.