As suggested by Cortese (105), orexin neurons located in the perifornical and dorsomedial hypothalamic areas (implicated in arousal) could be hypoactivated, while those located in the lateral hypothalamus (involved in reward processing, stimulating feeding, and other reward-seeking behaviors) could be overactivated in patients with ADHD. This evidence concerns the gene HCRT and attention deficit-hyperactivity disorder.