Accordingly, with the view that megalin expression is associated with the development of TII, it has been shown that megalin is involved in the genesis of different renal diseases (Piwon et al., 2000; Christensen et al., 2003; Batuman, 2007; Nakhoul and Batuman, 2011; Vicinanza et al., 2011; Gaide Chevronnay et al., 2014; Eshbach and Weisz, 2017; Wang et al., 2017; Cez et al., 2018; Larsen et al., 2018; Peruchetti et al., 2018; Silva-Aguiar et al., 2018). This evidence concerns the gene LRP2 and kidney disorder.