In addition, changes in megalin expression have been correlated with TII in Fanconi syndrome as well as autoimmune renal diseases (Piwon et al., 2000; Christensen et al., 2003; Batuman, 2007; Nakhoul and Batuman, 2011; Vicinanza et al., 2011; Gaide Chevronnay et al., 2014; Eshbach and Weisz, 2017; Wang et al., 2017; Cez et al., 2018). Here, LRP2 is linked to Fanconi renotubular syndrome.