For instance, Yu et al. (2014) suggested that pharmacogenomic profiling of invasive CTCs could predict chemotherapy response and resistance, whereas Steinert et al. (2014) identified upregulation of CD47 in concordance with the mark down-regulation of calreticulin, which were believed to mediate immune escape and survival mechanisms of CTCs in CRC. Here, CALR is linked to colorectal carcinoma.