APP and Alzheimer disease: As an important in vivo model in senescence-accelerated proneness, SAMP8 mice present age-related cognitive deterioration (Griñan-Ferré et al., 2016; Akiguchi et al., 2017) and show pathological features similar to the mechanisms responsible for AD pathophysiology, such as oxidative stress, APP overexpression, Aβ deposition and tau phosphorylation (Li et al., 2013; Bayod et al., 2014; Cheng et al., 2014).