At the same time, the proportion of cells that were positive for nuclear proliferation factor (Ki67), brain-derived neurotrophic factor (BDNF), and tumour angiogenesis marker (CD31) in tumours originating from miR-485-5p@SPIONs-HuGSCs were significantly lower than that of those originating from miR-mut@SPIONs-HuGSCs (Figure 6). The gene discussed is PECAM1; the disease is neoplasm.