Recent studies reported that EHMT2 was enriched on the promoters of key genes during autophagy including LC3B, WD repeat domain phosphoinositide-interacting protein 1 (WIPI1), the diabetes- and obesity-regulated gene (DOR) in a c-Jun-dependent manner and BECN1, as well as the expression of B-cell lymphoma 19-kDa interacting protein (BNIP) 36, 37. The gene discussed is WIPI1; the disease is obesity due to melanocortin 4 receptor deficiency.