Selective inhibitors of EHMT2 such as BIX01294 and BRD4770 could effectively enhance autophagy in various tumors, such as breast cancer,10 colon cancer,10 bladder cancer,11 oral squamous cell carcinoma,12 and neuroblastoma.13 EHMT2 together with RFX5, HDAC2, and Sin3B was reported to form a repressive chromatin structure surrounding the collagen gene transcription start site in response to IFN-γ stimulation, which is responsible for IFN-γ induced COL1A2 repression in VSMCs. The gene discussed is IFNG; the disease is oral cavity squamous cell carcinoma.