VGF and amyotrophic lateral sclerosis: Furthermore, there are several reports of the neuroprotective effects of VGF; 1) suppressing the death of cultured retinal ganglion cells 16, 2) enhancing the survival of cortical neurons 7, 3) VGF-derived peptide, AQEE-30, suppressed cell death in a model of Huntington's disease 17, and 4) induction of VGF by a pharmacological agent prolonged survival in a mouse model of ALS.