This observation is because this Lc3-mediated response occurs rapidly post-infection (within 1 hpi), the Lc3 signal labels the membrane of spacious phagosomal compartments, Lc3 recruitment does not require live Staphylococci, and Lc3 recruitment is independent of Sqstm1, suggesting damage to the phagosomal membrane is not required. The gene discussed is MAP1LC3A; the disease is infection.