Knockdown of ATP10B significantly increased the sensitivity of the cells to rotenone and MnCl2 (Figs. 4c, S9c, g, h), but not to bortezomib or ZnCl2 (Fig. S9e, f, I, j), which was also observed in our mutant ATP10B overexpressing models (Fig. 3f, g), strengthening our conclusion that loss of ATP10B functionality increases cell toxicity towards PD-related insults. Here, ATP10B is linked to Parkinson disease.