Moreover, both α-synuclein and the phospholipase PLA2G6, the latter implicated in neurodegeneration with brain iron accumulation and early-onset dystonia parkinsonism [52, 56], have been associated with changes in lysosomal ceramide levels, though the exact mechanisms are still unknown [57, 64, 69]. This evidence concerns the gene PLA2G6 and Parkinsonism.