To investigate whether ATP10B exerts a cell protective effect, stable cell lines were exposed to the heavy metals MnCl2 and ZnCl2, the 26S proteasome inhibitor bortezomib and the mitochondrial complex I inhibitor rotenone, stressors that evoked a phenotype in cell models of ATP13A2 loss of function, another late endo-lysosomal P-type ATPase implicated in PD [26, 48, 68]. The gene discussed is ATP10B; the disease is Parkinson disease.