KEAP1 and breast cancer: We observed the KEAP1 inhibitor DMF only increased NRF2 Nano-Luc signal in WT cells, however BC-1901S dose-dependently increased NRF2 Nano-Luc signal in both WT and KEAP1-KO cells, suggesting KEAP1 is not essential for BC-1901S effect (Fig. 5A, B).