The replication of the AHRR locus implicated in the PTSD-consortium EWAS in the discovery cohort, the replication of G0S2, the top locus from this EWAS, in the Consortium Military Meta-Analysis, and the broader evidence of agreement in effect size direction for the Discovery Cohort and the Replication Cohort are cause for renewed optimism in the search for reliable blood methylation-based PTSD biomarkers. Here, AHRR is linked to post-traumatic stress disorder.