In AE patients, regulatory IL-27, anti-inflammatory SDF-1/CXCL12, and eosinophil granulocytes attracting eotaxin-1, eotaxin-2 and eotaxin-3 (CCL11, CCL24 and CCL26) were enhanced with disease progression, while pro-inflammatory IL-31 and IL-33 were clearly depressed in all AE patients. The gene discussed is IL27; the disease is acrodermatitis enteropathica.