Of the 10 covariates, age (β = 0.301, p < 0.001), baseline memory score (β = 0.752, p value< 0.001), use of acetylcholinesterase inhibitor use (β = 0.212, p = 0.010), and baseline brain atrophy (β = 0.244, p < 0.001) were significantly associated with memory at month 12. The gene discussed is ACHE; the disease is Brain atrophy.