As it is reveled in Fig. 2a pituitary tumor tissues expressed higher level of COX-2 compared to normal pituitary tissue (P = 0.0001) with the mean and the standard error mean (SEM) of 0.4651 ± 0.02 and 0.1034 ± 0.01 for patients and control groups, respectively. The gene discussed is PTGS2; the disease is pituitary tumor.