PTGS2 and pituitary tumor: Notably, the COX-2 gene expression between pituitary tumor and normal tissue group showed the AUC level of 0.964 (95% CI, 0.926–1, P = 0.0001) and 0.18 as cut off with 90% sensitivity and specificity (Fig. 4c) while its expression between NFPAs and FPAs group showed the AUC level of 0.856 (95% CI, 0.763–0.949, P = 0.0001) and cut off value of 0.42 (86% sensitivity, 71% specificity) (Fig. 4d).