No similar studies were found to have evaluated the status of COX-1 expression in human pituitary adenoma; however, an elevated level of COX-2 expression was reported in pituitary carcinomas and oncocytic and non-oncocytic null-cell adenomas, although the methodology of that study differed from that of the current study [30, 31]. This evidence concerns the gene PTGS2 and pituitary gland adenoma.