TNF and Sepsis: If the 2011 criteria are used, our study fails to display a correlation between promoter SNP haplotypes and sepsis risk, as opposed to findings by Restas et al. They evidenced the protective role of minor frequency TNF-α SNP (including -308G/A and -238G/A) allele for some haplotypes in sepsis development, after failing to reach a similar result on the same patient group by using former definitions based on SIRS criteria [7, 68].