None of the SNPs in the TNF-α promoter, namely -308G/A,  -238G/A and -376G/A, showed an association with the risk of sepsis, although the frequency of the homozygous AA genotype of -308G/A SNP and respectively, of the heterozygote genotypes of all the three SNPs (no homozygous AA genotypes for  -238 and  -376 SNPs were found in the group) was increased in the sepsis group compared to controls (Supplemental Table 3). This evidence concerns the gene TNF and Sepsis.