Whereas increased B‐cell abundance with macrophage expansion accompanies airspace enlargement in COPD patients and aged mice, the findings here show that a distinct immune profile supports the acquired airspace enlargement in the aged IL10−/− lung (Calvi et al., 2011; Hogg et al., 2004; Polverino et al., 2015). Here, IL10 is linked to chronic obstructive pulmonary disease.