Accelerated FUS and TDP‐43 aggregates alter the dynamics and physiological properties of RNP granules even after stress is removed (Parker et al., 2012), and this results in persistent SGs that have been observed in cells expressing ALS‐associated TDP‐43 or FUS mutants (Bosco et al., 2010; Liu‐Yesucevitz et al., 2010). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.