Many RBPs, such as FUS, TDP‐43, hnRNPA1, hnRNPA2B1, hnRNPDL, and TIA‐1, are typical components of RNP granules, and their missense mutations have been identified in inherited forms of ALS, FTD, and myopathy (Kim et al., 2013; Klar et al., 2013; Kwiatkowski et al., 2009; Prasad, Bharathi, Sivalingam, Girdhar, & Patel, 2019; Sreedharan et al., 2008; Vieira et al., 2014). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.