These results suggest that in response to hyperlipidemia and in the absence of SR‐B1‐mediated transhepatic cholesterol movement, FXR activation could have elevated ileum cholesterol transporters (Abca1, Abcg1, Abcg5, and Abcg8) that led to enhanced cholesterol export from the enterocyte back into the lumen and excreted into feces. The gene discussed is NR1H4; the disease is hyperlipidemia.