NR1H4 and metabolic dysfunction-associated steatotic liver disease: FXR activation in rodents has also been shown to protect from atherosclerosis (Hartman et al., 2009) and nonalcoholic fatty liver disease (NAFLD) (Kong, Luyendyk, Tawfik, & Guo, 2009; Zhang, Wang, Liu, & Harnish, 2009).