Apart from a recent study, which demonstrated that administration of gelatin hydrogel containing epidermal growth factor improved neurological recovery after intracerebral hemorrhage (ICH) (Lim et al. 2019), the functional significance of EGFR signaling, as well as its key regulator such as E3 ubiquitin-protein ligase (Huangfu and Fuchs 2010), remains least explored after ICH. This evidence concerns the gene EGFR and intracerebral hemorrhage.