Further, the PANTHER-based analysis of proteomic data identified 67 different molecular pathways, and of those, the key pathways which were modulated between ICH and sham included blood coagulation, plasminogen activating cascade, p53 pathway, EGF receptor signaling pathway, FGF signaling pathway, cytoskeletal regulation by Rho GTPase, angiogenesis, integrin signaling pathway, Parkinson’s disease, Huntington disease, dopamine receptor mediated signaling pathway, T cell activation, and Wnt signaling (Fig. 5 and Supplementary data Table 3). Here, TP53 is linked to juvenile Huntington disease.