Furthermore, in contrast to the findings in this ASCAP study, low-grade adenosquamous carcinoma/syringomatous tumours of the breast, which contain p63 + and K5/14 + cells, first downregulate p63 and subsequently generate the K8/18 + glandularly differentiated cells via p63-negative K5/14 + intermediary cells indicating a different histogenetic pathway in these lesions compared to ASCAP tumours (Boecker et al. 2019; 2014). Here, KRT5 is linked to adenosquamous carcinoma.