As Yap1, Taz and Tead2 expression block migration of cells to the CP and, increase progenitors in the germinal zones, it is possible that the hyper-expansion of neural progenitors and miss-migration of immature neurons in Van Maldergem syndrome is caused, at least in part, by aberrant Tead2-induced transcription. This evidence concerns the gene TEAD2 and Cerebro-facio-articular syndrome.