A considerable increase in the AUC score for 6 combinations: CerP(23:1)/SM(40:1); S1P(20:2)/SM(18:2/22:0); S1P(20:2)/SM(40:1); S1P(22:2)/SM(18:2/22:0); S1P(22:2)/SM(40:1); SM(18:0/24:2)/SM(18:2/22:0)/SM(40:1) was observed suggesting that these sphingolipid metabolite sets can be used efficiently to distinguish tumor tissues from adjacent normal breast tissues. The gene discussed is ABCA1; the disease is neoplasm.