This is one of the index loci whose role in the disease pathophysiology is completely unclear, as the genes annotated to it (APOPT1, BAG5, KLC1, TRMT61A, XRCC3, CKB, PPP1R13B, LC1, AL0498, ZFYVE21) are not conventional candidates for schizophrenia and are not relevant to major hypotheses of the aetiology and treatment of the disease1. Here, COA8 is linked to schizophrenia.