COA8 and schizophrenia: A local polymorphism, rs28362583, is in strong linkage disequilibrium (LD) with the schizophrenia index SNP rs12887734 (D′ = 0.99, r2 = 0.92, European populations)44 and with rs7148456 (D′ = 0.99, r2 = 0.98) affecting alternative splicing of APOPT1 in the brain45.