Recently, we developed a 3D AD cellular model displaying both robust extracellular Aβ deposits (Aβ plaques) and Aβ-driven tau pathology, including somato-dendritic accumulation of p-tau and detergent-insoluble/silver-stained intracellular tau aggregation leading to neurofibrillary tangles (NFTs) and paired-helical filaments (PHFs)21,22. This evidence concerns the gene MAPT and Alzheimer disease.