R7:CAS3 mice exhibited fasting hyperglycemia (232.0 ± 38.6 mg/dl), compared with that seen in the R7:WTS3 (125.0 ± 15.9 mg/dl) mice, whereas the R7:DNS3 (68.4 ± 7.8 mg/dl) mice displayed lower fasting glucose levels when compared with their R7:WTS3 cohort (101.7 ± 15.8 mg/dl) (Fig. 3a, b). Here, EFS is linked to Hyperglycemia.