Moreover, when we examined the indel induction by NanoMEDIC containing 0.26 μg of active RNP complex with DMD1-sgRNA in DMD patient iPSCs, we found that it induced a higher percentage of indels versus 10 μg of electroporated recombinant RNP (Supplementary Fig. 7F). Here, RNPC3 is linked to Duchenne muscular dystrophy.