For example, reduced sensitivity to insulin is seen in some DMD and Becker muscular dystrophy human patients7,8,49, and insulin-related metabolic disorders (e.g., hyperinsulinemia, glucose intolerance, obesity) are seen in muscular dystrophies such as myotonic dystrophy type 1 and 249–51. The gene discussed is INS; the disease is myotonic dystrophy type 1.