The results showed that silencing Gm19897 did not affect the expression of nearby coding gene Sirt2 (Figure 9E), indicating that the role of Gm19897 on AD was not dependened on Sirt2. However, E230001N04Rik knockdown decreased the levels of its associated nearby coding genes Srpk1 and Fkbp5 (Figures 9F and 9G). This evidence concerns the gene SIRT2 and Alzheimer disease.