MAPT and frontotemporal dementia: Studies have shown that Srpk1 regulated the production of tau protein, which resulted in frontotemporal dementia;22,23 Fkbp5 interacted with Hsp90 to promote neurotoxic tau accumulation and increased tau stability,24,25 indicating that E230001N04Rik regulated tau protein accumulation by Srpk1 and/or Fkbp5 in AD progression.