In line with previous findings (Cortina et al., 2017, de Sousa e Melo et al., 2017, Shimokawa et al., 2017), we found that Lgr5 is a good marker of the functional SCs both in organoids and tumors, because selective ablation of the Lgr5+ CSCs by diphtheria toxin (DT) (Figures S1F–S1I) caused organoids to collapse and prevented tumor growth and metastasis (Figures 1B–1D). The gene discussed is LGR5; the disease is neoplasm.