MAPK3 and colorectal neoplasm: To study the role of CSCs in metastasis, we combined the VillinCre-ERT2; APCfl/fl; KRASLSL−G12D; TP53KO/KO colorectal tumor mouse model with Lgr5DTR/eGFP (de Sousa e Melo et al., 2017) and Confetti (Snippert et al., 2010) fluorescent mouse models (Figure 1A).