Consistent with other tumor models (Beerling et al., 2016, Hirata et al., 2015, Patsialou et al., 2013), in some tumor lobes no migration was observed, whereas in other lobes individual and clusters of Lgr5+ CSCs and Lgr5− cancer cells invaded into the non-labeled stroma (n = 9 mice, 73 movies, 1,064 migratory events; Figures 2A–2C; Figure S2A; Videos S1, S2, S3, and S4). This evidence concerns the gene LGR5 and cancer.