In this context, renal cell carcinoma (RCC) is one of the first and most assessed tumors by PSMA PET/CT imaging in the literature because it is a heavily vascularized tumor with well-documented PSMA expression in the neovasculature, as shown by immunohistochemistry and imaging studies [64, 66]. The gene discussed is FOLH1; the disease is hereditary clear cell renal cell carcinoma.