MTOR and Bloom syndrome: In line with these findings, our results in this study showed that pretreatment with MHY1485, a mTOR activator that potently inhibits autophagy, effectively attenuated the anti-inflammatory and anti-apoptotic effect of MVs in BLM-treated L2 cells, suggesting that MSC-MVs attenuate the BLM-induced apoptosis and inflammation via elevating autophagy.